Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels

Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels

The activity of serotonin (5-HT) neurons is critical for mood regulation. In a mouse model of chronic social isolation, a known risk factor for depressive illness, we show that 5-HT neurons in the dorsal raphe nucleus are less responsive to stimulation. Probing the responsible cellular mechanisms pi...

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Bibliographic Details
Main Authors: Derya Sargin, David K Oliver, Evelyn K Lambe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
dorsal raphe
serotonin neurons
social isolation
calcium-activated potassium channels
SK3
depressive-like behaviors
Online Access:https://elifesciences.org/articles/21416

Internet

https://elifesciences.org/articles/21416

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