Role of the Ang2–Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency

Role of the Ang2–Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency

Ablation of nucleoside diphosphate kinase B (NDPK-B) in mice causes a breakdown of the neurovascular unit in the retina, mimicking diabetic retinopathy. The NDPK-B deficiency-induced vascular damage is mediated by excessive angiopoietin 2 (Ang2). Herein, the potential involvement of its receptor, Ti...

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Bibliographic Details
Main Authors: Anupriya Chatterjee, Rachana Eshwaran, Hongpeng Huang, Di Zhao, Martina Schmidt, Thomas Wieland, Yuxi Feng
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
nucleoside diphosphate kinase B, NDPK-B
angiopoietin 2, Ang2
Tie2
vascular damage
endothelial cells
Online Access:https://www.mdpi.com/1422-0067/21/10/3713

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https://www.mdpi.com/1422-0067/21/10/3713

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