Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired muscle regeneration following injury in mice.

Bibliographic Details
Main Authors: Srinath C. Sampath, Srihari C. Sampath, Andrew T. V. Ho, Stéphane Y. Corbel, Joshua D. Millstone, John Lamb, John Walker, Bernd Kinzel, Christian Schmedt, Helen M. Blau
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03876-8

Internet

https://doi.org/10.1038/s41467-018-03876-8

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