Saccharomyces cerevisiae Differential Functionalization of Presumed ScALT1 and ScALT2 Alanine Transaminases Has Been Driven by Diversification of Pyridoxal Phosphate Interactions

Saccharomyces cerevisiae Differential Functionalization of Presumed ScALT1 and ScALT2 Alanine Transaminases Has Been Driven by Diversification of Pyridoxal Phosphate Interactions

Saccharomyces cerevisiae arose from an interspecies hybridization (allopolyploidiza-tion), followed by Whole Genome Duplication. Diversification analysis of ScAlt1/ScAlt2 indicated that while ScAlt1 is an alanine transaminase, ScAlt2 lost this activity, constituting an example in which one of the me...

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Bibliographic Details
Main Authors: Erendira Rojas-Ortega, Beatriz Aguirre-López, Horacio Reyes-Vivas, Martín González-Andrade, Jose C. Campero-Basaldúa, Juan P. Pardo, Alicia González
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
paralogous genes
pyridoxal phosphate binding
alanine transaminases
functional diversification
structural organization
alanine metabolism
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00944/full

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http://journal.frontiersin.org/article/10.3389/fmicb.2018.00944/full

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