Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation

Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation

SWI/SNF is a major regulator of gene expression. Its role is to facilitate the shifting and exposure of DNA segments within the promoter and other key domains to transcription factors and other essential cellular proteins. This complex interacts with a wide range of proteins and does not function w...

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Bibliographic Details
Main Authors: Stefanie eMarquez, Ken W Thompson, Li eLu, David eReisman
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Oncology
Subjects:
Chromatin remodeling
SMARCA4
Brahma
epigenetic BRG1
smarca2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00372/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00372/full

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