The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling.

The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling.

Beta-catenin plays an essential role in several biological events including cell fate determination, cell proliferation, and transformation. Here we report that beta-catenin is encoded by a labile transcript whose half-life is prolonged by Wnt and phosphatidylinositol 3-kinase-AKT signaling. AKT pho...

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Bibliographic Details
Main Authors: Roberto Gherzi, Michele Trabucchi, Marco Ponassi, Tina Ruggiero, Giorgio Corte, Christoph Moroni, Ching-Yi Chen, Khalid S Khabar, Jens S Andersen, Paola Briata
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.0050005

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https://doi.org/10.1371/journal.pbio.0050005

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