Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance
Chronic stress is a risk factor for mood disorders, yet the molecular and circuit mechanisms of stress-induced changes are not well understood. Here, the authors report the role of the transcription factor ΔFosB in driving activity changes in response to stress in glutamatergic neurons in the ventra...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17825-x |
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doaj-d4b95067e74845b094227a19382756112021-09-12T11:47:54ZengNature Publishing GroupNature Communications2041-17232020-09-0111111210.1038/s41467-020-17825-xCircuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidanceAndrew L. Eagle0Claire E. Manning1Elizabeth S. Williams2Ryan M. Bastle3Paula A. Gajewski4Amber Garrison5Alexis J. Wirtz6Seda Akguen7Katie Brandel-Ankrapp8Wilson Endege9Frederick M. Boyce10Yoshinori N. Ohnishi11Michelle Mazei-Robison12Ian Maze13Rachel L. Neve14Alfred J. Robison15Department of Physiology, Michigan State UniversityDepartment of Physiology, Michigan State UniversityDepartment of Physiology, Michigan State UniversityDepartment of Neuroscience, Icahn School of Medicine, Mount SinaiDepartment of Physiology, Michigan State UniversityDepartment of Physiology, Michigan State UniversityDepartment of Physiology, Michigan State UniversityDepartment of Physiology, Michigan State UniversityDepartment of Physiology, Michigan State UniversityDepartment of Neurology, Massachusetts General HospitalDepartment of Neurology, Massachusetts General HospitalDepartment of Pharmacology, Kurume University School of MedicineDepartment of Physiology, Michigan State UniversityDepartment of Neuroscience, Icahn School of Medicine, Mount SinaiGene Technology Transfer Core, Massachusetts General HospitalDepartment of Physiology, Michigan State UniversityChronic stress is a risk factor for mood disorders, yet the molecular and circuit mechanisms of stress-induced changes are not well understood. Here, the authors report the role of the transcription factor ΔFosB in driving activity changes in response to stress in glutamatergic neurons in the ventral hippocampus that project to nucleus accumben.https://doi.org/10.1038/s41467-020-17825-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Andrew L. Eagle Claire E. Manning Elizabeth S. Williams Ryan M. Bastle Paula A. Gajewski Amber Garrison Alexis J. Wirtz Seda Akguen Katie Brandel-Ankrapp Wilson Endege Frederick M. Boyce Yoshinori N. Ohnishi Michelle Mazei-Robison Ian Maze Rachel L. Neve Alfred J. Robison |
| spellingShingle |
Andrew L. Eagle Claire E. Manning Elizabeth S. Williams Ryan M. Bastle Paula A. Gajewski Amber Garrison Alexis J. Wirtz Seda Akguen Katie Brandel-Ankrapp Wilson Endege Frederick M. Boyce Yoshinori N. Ohnishi Michelle Mazei-Robison Ian Maze Rachel L. Neve Alfred J. Robison Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance Nature Communications |
| author_facet |
Andrew L. Eagle Claire E. Manning Elizabeth S. Williams Ryan M. Bastle Paula A. Gajewski Amber Garrison Alexis J. Wirtz Seda Akguen Katie Brandel-Ankrapp Wilson Endege Frederick M. Boyce Yoshinori N. Ohnishi Michelle Mazei-Robison Ian Maze Rachel L. Neve Alfred J. Robison |
| author_sort |
Andrew L. Eagle |
| title |
Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance |
| title_short |
Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance |
| title_full |
Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance |
| title_fullStr |
Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance |
| title_full_unstemmed |
Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance |
| title_sort |
circuit-specific hippocampal δfosb underlies resilience to stress-induced social avoidance |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-09-01 |
| description |
Chronic stress is a risk factor for mood disorders, yet the molecular and circuit mechanisms of stress-induced changes are not well understood. Here, the authors report the role of the transcription factor ΔFosB in driving activity changes in response to stress in glutamatergic neurons in the ventral hippocampus that project to nucleus accumben. |
| url |
https://doi.org/10.1038/s41467-020-17825-x |
| work_keys_str_mv |
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1717755425180352512 |