Germline BAP1 inactivation is preferentially associated with metastatic ocular melanoma and cutaneous-ocular melanoma families.

Germline BAP1 inactivation is preferentially associated with metastatic ocular melanoma and cutaneous-ocular melanoma families.

BACKGROUND:BAP1 has been shown to be a target of both somatic alteration in high-risk ocular melanomas (OM) and germline inactivation in a few individuals from cancer-prone families. These findings suggest that constitutional BAP1 changes may predispose individuals to metastatic OM and that familial...

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Bibliographic Details
Main Authors: Ching-Ni Jenny Njauw, Ivana Kim, Adriano Piris, Michele Gabree, Michael Taylor, Anne Marie Lane, Margaret M DeAngelis, Evangelos Gragoudas, Lyn M Duncan, Hensin Tsao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3335872?pdf=render

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http://europepmc.org/articles/PMC3335872?pdf=render

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