Synergic effect of combined cyclosporin and melatonin protects the brain against acute ischemic reperfusion injury

Background: This study tested whether combined cyclosporin-A (CsA) and melatonin (Mel) was superior to either one on protecting the brain against ischemia (occluded left-middle-cerebral-artery for 90-min)-reperfusion (for 14 days) injury. Methods and results: Neuro-2a cells (N2a) were categorized in...

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Bibliographic Details
Main Authors: Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei‐Hsun Sung, Yi-Ching Chu, Hon‐Kan Yip
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221000512