Disruption of Structural Disulfides of Coagulation FXIII-B Subunit; Functional Implications for a Rare Bleeding Disorder

Disruption of Structural Disulfides of Coagulation FXIII-B Subunit; Functional Implications for a Rare Bleeding Disorder

Congenital FXIII deficiency is a rare bleeding disorder in which mutations are detected in <i>F13A1</i> and <i>F13B</i> genes that express the two subunits of coagulation FXIII, the catalytic FXIII-A, and protective FXIII-B. Mutations in FXIII-B subunit are considerably rarer...

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Bibliographic Details
Main Authors: Sneha Singh, Mohammad Suhail Akhter, Johannes Dodt, Amit Sharma, Senthilvelrajan Kaniyappan, Hamideh Yadegari, Vytautas Ivaskevicius, Johannes Oldenburg, Arijit Biswas
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
coagulation Factor XIII
FXIII-B
disulfide bonds
FXIII deficiency
Online Access:https://www.mdpi.com/1422-0067/20/8/1956

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https://www.mdpi.com/1422-0067/20/8/1956

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