Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

Abstract Background Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved in these long-term treatment failure...

Full description

Bibliographic Details
Main Authors: Maria Elena Pisanu, Marcello Maugeri-Saccà, Luigi Fattore, Sara Bruschini, Claudia De Vitis, Eugenio Tabbì, Barbara Bellei, Emilia Migliano, Daniela Kovacs, Emanuela Camera, Mauro Picardo, Ziga Jakopin, Claudia Cippitelli, Armando Bartolazzi, Salvatore Raffa, Maria Rosaria Torrisi, Franco Fulciniti, Paolo A. Ascierto, Gennaro Ciliberto, Rita Mancini
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lipid metabolism
Melanoma cancer stem cells
BRAF
MEK inhibitors
Online Access:http://link.springer.com/article/10.1186/s13046-018-0989-7

Internet

http://link.springer.com/article/10.1186/s13046-018-0989-7

Similar Items