Region specific and worldwide distribution of collagen-binding M proteins with PARF motifs among human pathogenic streptococcal isolates.

Some of the variety of Streptococcus pyogenes and Streptococcus dysgalactiae ssp. equisimilis (SDSE) M proteins act as collagen-binding adhesins that facilitate acute infection. Moreover, their potential to trigger collagen autoimmunity has been implicated in the pathogenesis of acute rheumatic feve...

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Main Authors: Silvana Reissmann, Christine M Gillen, Marcus Fulde, René Bergmann, Andreas Nerlich, Reena Rajkumari, Kootallur N Brahmadathan, Gursharan S Chhatwal, D Patric Nitsche-Schmitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22253902/pdf/?tool=EBI