Possible New Strategies for the Treatment of Congenital Hyperinsulinism

Possible New Strategies for the Treatment of Congenital Hyperinsulinism

ObjectiveCongenital hyperinsulinism (CHI) is a rare disease characterized by persistent hypoglycemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants. Poor efficacy and strong adverse effects of the current medications impede successful t...

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Bibliographic Details
Main Authors: Jelena Sikimic, Theresa Hoffmeister, Anne Gresch, Julia Kaiser, Winfried Barthlen, Carmen Wolke, Ilse Wieland, Uwe Lendeckel, Peter Krippeit-Drews, Martina Düfer, Gisela Drews
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Endocrinology
Subjects:
congenital hyperinsulinism
KATP channels
diazoxide
NN414
L-type Ca2+ channels
KCa3.1 channels
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.545638/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.545638/full

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