Characterization of receptor tyrosine kinase activation and biological activity of toceranib phosphate in canine urothelial carcinoma cell lines

Abstract Background Urothelial carcinoma (UC) accounts for > 90% of canine tumors occurring in the urinary bladder. Toceranib phosphate (TOC) is a multi-target receptor tyrosine kinase (RTK) inhibitor that exhibits activity against members of the split kinase family of RTKs. The purpose of this s...

Full description

Bibliographic Details
Main Authors: Daniela I. Korec, Darian S. Louke, Justin T. Breitbach, Jennifer A. Geisler, Brian D. Husbands, Joelle M. Fenger
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Veterinary Research
Subjects:
Online Access:https://doi.org/10.1186/s12917-021-03027-0