Real-time <it>in vivo </it>imaging of <it>p16</it><sup><it>Ink4a </it></sup>gene expression: a new approach to study senescence stress signaling in living animals
<p>Abstract</p> <p>Oncogenic proliferative signals are coupled to a variety of growth inhibitory processes. In cultured primary human fibroblasts, for example, ectopic expression of oncogenic Ras or its downstream mediator initiates cellular senescence, the state of irreversible ce...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-01-01
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| Series: | Cell Division |
| Online Access: | http://www.celldiv.com/content/5/1/1 |