High Doses of Bupleurum falcatum Partially Prevents Estrogen Deficiency-Induced Bone Loss With Anti-osteoclastogenic Activity Due to Enhanced iNOS/NO Signaling

High Doses of Bupleurum falcatum Partially Prevents Estrogen Deficiency-Induced Bone Loss With Anti-osteoclastogenic Activity Due to Enhanced iNOS/NO Signaling

Background and Objective:Bupleurum falcatum (BF) extract, a natural product with anti-inflammatory properties, has been traditionally used to treat menopausal symptoms, but its role in osteoporosis, another serious health concern of menopausal women, remains unknown. Here we investigated whether and...

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Bibliographic Details
Main Authors: Mijung Yeom, Eun-Young Kim, Jae-Hyun Kim, Hyuk-Sang Jung, Youngjoo Sohn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
Bupleurum falcatum
postmenopausal osteoporosis
bone resorption
osteoclasts
ovariectomized rats
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01314/full

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