Improving the Safety of Cell Therapy Products by Suicide Gene Transfer

Improving the Safety of Cell Therapy Products by Suicide Gene Transfer

Adoptive T-cell therapy can involve donor lymphocyte infusion (DLI) after allogeneic hematopoietic stem cell transplantation, the administration of tumor infiltrating lymphocyte (TILs) expanded ex-vivo, or more recently the use of T cell receptor (TCR) or chimeric antigen receptor (CAR) redirect...

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Bibliographic Details
Main Authors: Antonio eDi Stasi, Benjamin Scott Jones, Lawrence S. Lamb, Frederick eGoldman
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Pharmacology
Subjects:
cell therapy
Suicide gene
HSV-tk
iCasp9
CAR T cells
TCR redirected T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00254/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00254/full

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