Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System

Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System

The blood-brain barrier (BBB) is responsible for the homeostasis between the cerebral vasculature and the brain and it has a key role in regulating the influx and efflux of substances, in healthy and diseased states. Stem cell technology offers the opportunity to use human brain-specific cells to es...

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Bibliographic Details
Main Authors: Annalise Di Marco, Domenico Vignone, Odalys Gonzalez Paz, Ivan Fini, Maria Rosaria Battista, Antonella Cellucci, Elena Bracacel, Giulio Auciello, Maria Veneziano, Vinod Khetarpal, Mark Rose, Alessandro Rosa, Isabelle Gloaguen, Edith Monteagudo, Todd Herbst, Celia Dominguez, Ignacio Muñoz-Sanjuán
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
blood brain barrier
human induced pluripotent stem cells
CNS
permeability
Huntington’s disease
Online Access:https://www.mdpi.com/2073-4409/9/4/994

Internet

https://www.mdpi.com/2073-4409/9/4/994

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