Akt-signal integration is involved in the differentiation of embryonal carcinoma cells.

Akt-signal integration is involved in the differentiation of embryonal carcinoma cells.

The mechanism by which Akt modulates stem cell homeostasis is still incompletely defined. Here we demonstrate that Akt phosphorylates special AT-rich sequences binding protein 1 (SATB1) at serine 47 and protects SATB1 from apoptotic cleavage. Meanwhile, Akt phosphorylates Oct4 at threonine 228 and K...

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Bibliographic Details
Main Authors: Bo Chen, Zheng Xue, Guanghui Yang, Bingyang Shi, Ben Yang, Yuemin Yan, Xue Wang, Daishu Han, Yue Huang, Wenji Dong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3675137?pdf=render

Internet

http://europepmc.org/articles/PMC3675137?pdf=render

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