T Lymphocytes in Patients With Nijmegen Breakage Syndrome Demonstrate Features of Exhaustion and Senescence in Flow Cytometric Evaluation of Maturation Pathway

T Lymphocytes in Patients With Nijmegen Breakage Syndrome Demonstrate Features of Exhaustion and Senescence in Flow Cytometric Evaluation of Maturation Pathway

Patients with Nijmegen Breakage Syndrome (NBS) suffer from recurrent infections due to humoral and cellular immune deficiency. Despite low number of T lymphocytes and their maturation defect, the clinical manifestations of cell-mediated deficiency are not as severe as in case of patients with other...

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Bibliographic Details
Main Authors: Barbara Piatosa, Beata Wolska-Kuśnierz, Katarzyna Tkaczyk, Edyta Heropolitanska-Pliszka, Urszula Grycuk, Anna Wakulinska, Hanna Gregorek
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
Nijmegen Breakage Syndrome
T lymphocyte maturation
flow cytometry
primary immune deficiency
immune senescence
immune exhaustion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01319/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01319/full

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