Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease

Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease

The loss of dopaminergic neurons (DA) is a pathological hallmark of sporadic and familial forms of Parkinson's disease (PD). We have previously shown that inhibiting mitochondrial calcium uniporter (mcu) using morpholinos can rescue DA neurons in the PTEN-induced putative kinase 1 (pink1)−/− ze...

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Bibliographic Details
Main Authors: Smijin K. Soman, Michal Bazała, Marcus Keatinge, Oliver Bandmann, Jacek Kuznicki
Format: Article
Language:English
Published: The Company of Biologists 2019-10-01
Series:Biology Open
Subjects:
mitochondria
mcu
parkinson's disease
zebrafish
crispr/cas9
neuroprotection
Online Access:http://bio.biologists.org/content/8/10/bio044347

Internet

http://bio.biologists.org/content/8/10/bio044347

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