Mechanisms of the Osteogenic Switch of Smooth Muscle Cells in Vascular Calcification: WNT Signaling, BMPs, Mechanotransduction, and EndMT

Mechanisms of the Osteogenic Switch of Smooth Muscle Cells in Vascular Calcification: WNT Signaling, BMPs, Mechanotransduction, and EndMT

Characterized by the hardening of arteries, vascular calcification is the deposition of hydroxyapatite crystals in the arterial tissue. Calcification is now understood to be a cell-regulated process involving the phenotypic transition of vascular smooth muscle cells into osteoblast-like cells. There...

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Bibliographic Details
Main Authors: John Tyson, Kaylee Bundy, Cameron Roach, Hannah Douglas, Valerie Ventura, Mary Frances Segars, Olivia Schwartz, C. LaShan Simpson
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Bioengineering
Subjects:
vascular calcification
smooth muscle cells
canonical WNT
RUNX2
BMPs
integrins
Online Access:https://www.mdpi.com/2306-5354/7/3/88

Internet

https://www.mdpi.com/2306-5354/7/3/88

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