Lagrangian Trajectories to Predict the Formation of Population Heterogeneity in Large-Scale Bioreactors
Successful scale-up of bioprocesses requires that laboratory-scale performance is equally achieved during large-scale production to meet economic constraints. In industry, heuristic approaches are often applied, making use of physical scale-up criteria that do not consider cellular needs or properti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-03-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2306-5354/4/2/27 |