Lagrangian Trajectories to Predict the Formation of Population Heterogeneity in Large-Scale Bioreactors

Lagrangian Trajectories to Predict the Formation of Population Heterogeneity in Large-Scale Bioreactors

Successful scale-up of bioprocesses requires that laboratory-scale performance is equally achieved during large-scale production to meet economic constraints. In industry, heuristic approaches are often applied, making use of physical scale-up criteria that do not consider cellular needs or properti...

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Bibliographic Details
Main Authors: Maike Kuschel, Flora Siebler, Ralf Takors
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Bioengineering
Subjects:
computational fluid dynamics
cell cycle model
Lagrange trajectory
scale-up
stirred tank reactor
population dynamics
energy level
Online Access:http://www.mdpi.com/2306-5354/4/2/27

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http://www.mdpi.com/2306-5354/4/2/27

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