Involvement of 5-HT1A/1B receptors in the antinociceptive effect of paracetamol in the rat formalin test

The mechanism of analgesic action of paracetamol (acetominophen) remains still unknown. However, a relationship between serotonergic system and the effect of paracetamol has been previously demonstrated. The serotonin activity in the brainstem is primarily under the control of 5-HT1A somatodendritic...

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Bibliographic Details
Main Authors: A. Roca-Vinardell, E. Berrocoso, M. Llorca-Torralba, J.A. García-Partida, J. Gibert-Rahola, J.A. Mico
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Neurobiology of Pain
Online Access:http://www.sciencedirect.com/science/article/pii/S2452073X17300260