Assessing the accuracy of ancestral protein reconstruction methods.

The phylogenetic inference of ancestral protein sequences is a powerful technique for the study of molecular evolution, but any conclusions drawn from such studies are only as good as the accuracy of the reconstruction method. Every inference method leads to errors in the ancestral protein sequence,...

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Bibliographic Details
Main Authors: Paul D Williams, David D Pollock, Benjamin P Blackburne, Richard A Goldstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.0020069