Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats

Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats

Abstract Background To date the TGF-β1 activation mediated by integrin ανβ5 during fibrosis is well-known. This process has been shown also in the heart, where cardiac fibroblasts (CF) differentiate into α-smooth muscle actin (α-SMA)-positive myofibroblasts (MyoFB). Here, we studied the effects on C...

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Bibliographic Details
Main Authors: Gianluca Lorenzo Perrucci, Veronica Antonietta Barbagallo, Maria Corlianò, Delfina Tosi, Rosaria Santoro, Patrizia Nigro, Paolo Poggio, Gaetano Bulfamante, Federico Lombardi, Giulio Pompilio
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Translational Medicine
Subjects:
Hypertension
Myofibroblast
TGF-β1
Integrin ανβ5
Cilengitide
Online Access:http://link.springer.com/article/10.1186/s12967-018-1730-1

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http://link.springer.com/article/10.1186/s12967-018-1730-1

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