Brain Microvascular Endothelial Cell-Derived HMGB1 Facilitates Monocyte Adhesion and Transmigration to Promote JEV Neuroinvasion

Brain Microvascular Endothelial Cell-Derived HMGB1 Facilitates Monocyte Adhesion and Transmigration to Promote JEV Neuroinvasion

Infection with Japanese encephalitis virus (JEV) induces high morbidity and mortality, including potentially permanent neurological sequelae. However, the mechanisms by which viruses cross the blood-brain barrier (BBB) and invade into the central nervous system (CNS) remain unclear. Here, we show th...

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Bibliographic Details
Main Authors: Song-Song Zou, Qing-Cui Zou, Wen-Jing Xiong, Ning-Yi Cui, Ke Wang, Hao-Xuan Liu, Wen-Juan Lou, Doaa Higazy, Ya-Ge Zhang, Min Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
transmigration
adhesion
monocyte
HMGB1
Japanese encephalitis virus (JEV)
neuroinvasion
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.701820/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.701820/full

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