Role of Lipopolysaccharide in Protecting OmpT from Autoproteolysis during In Vitro Refolding

Outer membrane protease (OmpT) is a 33.5 kDa aspartyl protease that cleaves at dibasic sites and is thought to function as a defense mechanism for <i>E. coli</i> against cationic antimicrobial peptides secreted by the host immune system. Despite carrying three dibasic sites in its own se...

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Bibliographic Details
Main Authors: Gaurav Sinsinbar, Sushanth Gudlur, Kevin J Metcalf, Milan Mrksich, Madhavan Nallani, Bo Liedberg
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomolecules
Subjects:
LPS
Online Access:https://www.mdpi.com/2218-273X/10/6/922