Crystal Structures of the 43 kDa ATPase Domain of <i>Xanthomonas Oryzae</i> pv. <i>Oryzae</i> Topoisomerase IV ParE Subunit and its Complex with Novobiocin

Topoisomerase IV, one of the best-established antibacterial targets, is an enzyme crucial for chromosome segregation and cell division by catalyzing changes in DNA topology through breaking and rejoining DNA. This enzyme functions as a heterotetramer consisting of two ParC and two ParE subunits. Ami...

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Bibliographic Details
Main Authors: Ha Yun Jung, Yong-Seok Heo
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Crystals
Subjects:
Online Access:https://www.mdpi.com/2073-4352/9/11/577