Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization

Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization

Background: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity. High doses or prolonged exposure to CPS induces TRPV1 defunctionalization and, although this effect is currently used for the treatment of thermal hyperal...

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Bibliographic Details
Main Authors: Carmelo Puglia, Debora Santonocito, Angela Bonaccorso, Teresa Musumeci, Barbara Ruozi, Rosario Pignatello, Claudia Carbone, Carmela Parenti, Santina Chiechio
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
capsaicin
TRPV1 agonist
lipid nanocarrier (LN)
atomic force microscopy (AFM)
in vitro release
spontaneous pain
Online Access:https://www.mdpi.com/1999-4923/12/4/339

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https://www.mdpi.com/1999-4923/12/4/339

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