Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration

Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration

Synthesis of new 1-aryl-3-substituted propanol derivatives followed by structure-activity relationship, in silico drug-likeness, cytotoxicity, genotoxicity, in silico metabolism, in silico pharmacophore modeling, and in vivo studies led to the identification of compounds 22 and 23 with significant i...

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Bibliographic Details
Main Authors: Miguel Quiliano, Adela Mendoza, Kim Y. Fong, Adriana Pabón, Nathan E. Goldfarb, Isabelle Fabing, Ariane Vettorazzi, Adela López de Cerain, Ben M. Dunn, Giovanny Garavito, David W. Wright, Eric Deharo, Silvia Pérez-Silanes, Ignacio Aldana, Silvia Galiano
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Antimalarial
Antiplasmodial
Arylamino alcohol
Plasmepsin II enzyme
Hemozoin inhibition
Mannich reaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320716300446

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http://www.sciencedirect.com/science/article/pii/S2211320716300446

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