Intracerebroventricular Administration of Interferon-Alpha Induced Depressive-Like Behaviors and Neurotransmitter Changes in Rhesus Monkeys

Intracerebroventricular Administration of Interferon-Alpha Induced Depressive-Like Behaviors and Neurotransmitter Changes in Rhesus Monkeys

Interferon-alpha (IFN-α) is a cytokine widely used in the treatment of brain cancers and virus infections with side effects including causing depression. Monoamine neurotransmitter systems have been found playing important roles in peripheral IFN-α-induced depression, but how peripheral IFN-α access...

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Bibliographic Details
Main Authors: Zhifei Li, Zhaoxia Li, Xiaoman Lv, Zhaofu Li, Lei Xiong, Xintian Hu, Dongdong Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroscience
Subjects:
interferon-alpha
intracerebroventricular administration
rhesus monkeys
depressive-like behaviors
neurotransmitters
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.585604/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.585604/full

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