Anthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune response.
Many pathogens have acquired strategies to combat the immune response. Bacillus anthracis interferes with host defenses by releasing anthrax lethal toxin (LT), which inactivates mitogen-activated protein kinase pathways, rendering dendritic cells (DCs) and T lymphocytes nonresponsive to immune stimu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-10-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC1266308?pdf=render |