Preservation of biological function despite oxidative modification of the apolipoprotein A-I mimetic peptide 4F

Preservation of biological function despite oxidative modification of the apolipoprotein A-I mimetic peptide 4F

Myeloperoxidase (MPO)-derived hypochlorous acid induces changes in HDL function via redox modifications at the level of apolipoprotein A-I (apoA-I). As 4F and apoA-I share structural and functional properties, we tested the hypothesis that 4F acts as a reactive substrate for hypochlorous acid (HOCl)...

Full description

Bibliographic Details
Main Authors: C. Roger White, Geeta Datta, Amanda K.W. Buck, Manjula Chaddha, Gautam Reddy, Landon Wilson, Mayakonda N. Palgunachari, Mohammad Abbasi, G.M. Anantharamaiah
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Journal of Lipid Research
Subjects:
hypochlorous acid
tryptophan
oxidation
cholesterol efflux
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418619

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520418619

Similar Items