New α- and SIN γ-retrovectors for safe transduction and specific transgene expression in pancreatic β cell lines

New α- and SIN γ-retrovectors for safe transduction and specific transgene expression in pancreatic β cell lines

Abstract Background Viral vectors are invaluable tools to transfer genes and/or regulatory sequences into differentiated cells such as pancreatic cells. To date, several kinds of viral vectors have been used to transduce different pancreatic cell types, including insulin-producing β cells. However,...

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Bibliographic Details
Main Authors: Olivier Albagli, Alicia Maugein, Lukas Huijbregts, Delphine Bredel, Géraldine Carlier, Patrick Martin, Raphaël Scharfmann
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Biotechnology
Subjects:
α-Retrovector
SIN γ-retrovector
Pancreatic β cell lines
EndoC-β H2 cells
Rat insulin promoter
BXV1 xenotropic retrovirus
Online Access:http://link.springer.com/article/10.1186/s12896-019-0531-9

Internet

http://link.springer.com/article/10.1186/s12896-019-0531-9

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