Maackiain Ameliorates 6-Hydroxydopamine and <i>SNCA</i> Pathologies by Modulating the PINK1/Parkin Pathway in Models of Parkinson’s Disease in <i>Caenorhabditis elegans</i> and the SH-SY5Y Cell Line
The movement disorder Parkinson’s disease (PD) is the second most frequently diagnosed neurodegenerative disease, and is associated with aging, the environment, and genetic factors. The intracellular aggregation of α-synuclein and the loss of dopaminergic neurons in the substantia nigra pars compact...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/12/4455 |