Loss-of-function phenotype of a PKCθT219A knockin mouse strain

Loss-of-function phenotype of a PKCθT219A knockin mouse strain

Abstract Background Protein kinase C θ has been established as an important signaling intermediate in T-effector-cell activation and survival pathways by controlling activity of the key transcription factors NF-κB and NFAT. Previous studies identified an activation-induced auto-phosphorylation site...

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Bibliographic Details
Main Authors: Nikolaus Thuille, Kerstin Siegmund, Victoria Klepsch, Jacqueline Schörgenhuber, Sarah Danklmaier, Michael Leitges, Gottfried Baier
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cell Communication and Signaling
Subjects:
T cell activation
Protein kinase C θ (PKC θ)
Thr-219 autophosphorylation site
Interleukin 2 (IL-2) production
NF-κB
NFAT
Online Access:http://link.springer.com/article/10.1186/s12964-019-0466-8

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http://link.springer.com/article/10.1186/s12964-019-0466-8

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