The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: <i>Actionable Perspectives</i>

The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: <i>Actionable Perspectives</i>

Insulin receptor overexpression is a common event in human cancer. Its overexpression is associated with a relative increase in the expression of its isoform A (IR<b><sup>A</sup></b>), a shorter variant lacking 11 aa in the extracellular domain, conferring high affinity for t...

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Bibliographic Details
Main Authors:	Pierluigi Scalia, Antonio Giordano, Stephen J. Williams
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Cancers
Subjects:	igf(i/ii/1r), insulin-like growth factor (1 or 2 or receptor) ir<b><sup>a</sup></b>/ir-a insulin receptor isoform a igfbp igf binding protein itn integrin m6pr mannose 6 phosphate receptor tf transferrin vtn vitronectin hif hypoxia-inducible factor vhl von hippel-lindau gene product oct off-context targeting
Online Access:	https://www.mdpi.com/2072-6694/12/2/366

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