The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: <i>Actionable Perspectives</i>

The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: <i>Actionable Perspectives</i>

Insulin receptor overexpression is a common event in human cancer. Its overexpression is associated with a relative increase in the expression of its isoform A (IR<b><sup>A</sup></b>), a shorter variant lacking 11 aa in the extracellular domain, conferring high affinity for t...

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Bibliographic Details
Main Authors: Pierluigi Scalia, Antonio Giordano, Stephen J. Williams
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
igf(i/ii/1r), insulin-like growth factor (1 or 2 or receptor)
ir<b><sup>a</sup></b>/ir-a
insulin receptor isoform a
igfbp
igf binding protein
itn
integrin
m6pr
mannose 6 phosphate receptor
tf
transferrin
vtn
vitronectin
hif
hypoxia-inducible factor
vhl
von hippel-lindau gene product
oct
off-context targeting
Online Access:https://www.mdpi.com/2072-6694/12/2/366

Internet

https://www.mdpi.com/2072-6694/12/2/366

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