Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design

Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design

The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells. Despite a wealth of information about peptidases involved in protein degradation, our knowledge of...

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Bibliographic Details
Main Authors: Marijana Rucevic, Julie Boucau, Jens Dinter, Georgio Kourjian, Sylvie Le Gall
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Viruses
Subjects:
HIV
antigen processing
protein degradation
proteasome
aminopeptidase
peptidase
immunogen
vaccine vector
dendritic cells
T cells
viral evolution
Online Access:http://www.mdpi.com/1999-4915/6/8/3271

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http://www.mdpi.com/1999-4915/6/8/3271

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