Quantifying arrhythmic long QT effects of hydroxychloroquine and azithromycin with whole-heart optical mapping and simulations

Quantifying arrhythmic long QT effects of hydroxychloroquine and azithromycin with whole-heart optical mapping and simulations

Background: In March 2020, hydroxychloroquine (HCQ) alone or combined with azithromycin (AZM) was authorized as a treatment for COVID-19 in many countries. The therapy proved ineffective with long QT and deadly cardiac arrhythmia risks, illustrating challenges to determine the new safety profile of...

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Bibliographic Details
Main Authors: Ilija Uzelac, PhD, MBA, Abouzar Kaboudian, PhD, Shahriar Iravanian, MD, MSE, Jimena G. Siles-Paredes, MSc, James C. Gumbart, PhD, Hiroshi Ashikaga, MD, PhD, Neal Bhatia, MD, FHRS, Robert F. Gilmour, Jr., PhD, Elizabeth M. Cherry, PhD, Flavio H. Fenton, PhD
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Heart Rhythm O2
Subjects:
Alternans
Action potential
Arrhythmias
Azithromycin
COVID-19
Cardiotoxic drugs
Online Access:http://www.sciencedirect.com/science/article/pii/S2666501821001173

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http://www.sciencedirect.com/science/article/pii/S2666501821001173

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