Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin

Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin

<p>Abstract</p> <p>Background</p> <p>Malignant mesotheliomas (MM) have a poor prognosis, largely because of their chemoresistance to anti-cancer drugs such as doxorubicin (Dox). Here we show using human MM lines that Dox activates extracellular signal-regulated kinases...

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Bibliographic Details
Main Authors: Carbone Michele, Pass Harvey I, Vacek Pamela M, Beuschel Stacie L, MacPherson Maximilian B, Hillegass Jedd M, Shukla Arti, Testa Joseph R, Mossman Brooke T
Format: Article
Language:English
Published: BMC 2010-12-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/314

Internet

http://www.molecular-cancer.com/content/9/1/314

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