A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability

A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability

ABSTRACT Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of zidovudine. SDs were prepared using the co-precipitation method follo...

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Bibliographic Details
Main Authors: Liliane Neves Pedreiro, Beatriz Stringhetti Ferreira Cury, Marco Vinícius Chaud, Maria Palmira Daflon Gremião
Format: Article
Language:English
Published: Universidade de São Paulo
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Zidovudine
Solid dispersion
Mucoadhesion
P-glycoprotein
Intestinal permeability.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400715&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400715&lng=en&tlng=en

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