Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.

Although acute lung injury (ALI) is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria (CM); however, no model of m...

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Bibliographic Details
Main Authors: Fiona E Lovegrove, Sina A Gharib, Lourdes Peña-Castillo, Samir N Patel, John T Ruzinski, Timothy R Hughes, W Conrad Liles, Kevin C Kain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2364663?pdf=render