m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis

m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis

N6-methyladenosine (m6A) modification has been reported as a critical regulator of gene transcript expression. Although m6A modification plays important roles in tumor development, its role in therapeutic resistance remains unknown. In this study, we aimed to examine the expression level of m6A-modi...

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Bibliographic Details
Main Authors: Jun-Ju He, Zhi Li, Zhuo-Xian Rong, Jie Gao, Yun Mu, Yi-Di Guan, Xin-Xin Ren, Yu-Yuan Zi, Li-Yu Liu, Qi Fan, Ming Zhou, Yu-Mei Duan, Qin Zhou, Yue-Zhen Deng, Lun-Quan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
m6A
YTHDC2
nasopharyngeal carcinoma
IGF1R
PI3K-AKT signaling
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01166/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01166/full

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