Novel Cytotoxic Vectors Based on Adeno-Associated Virus

Vectors based on adeno-associated virus (AAV) are promising tools for gene therapy. The production of strongly toxic vectors, for example for cancer-directed gene transfer, is often unfeasible due to uncontrolled expression of toxic genes in vector-producing cells. Using an approach based on transcr...

Full description

Bibliographic Details
Main Authors: Johannes Kohlschütter, Martin Trepel, Stefan Michelfelder
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/2/12/2754/