Lisdexamfetamine prodrug activation by peptidase-mediated hydrolysis in the cytosol of red blood cells

Johannah Sharman, Michael Pennick Shire, Basingstoke, UK Abstract: Lisdexamfetamine dimesylate (LDX) is approved as a once-daily treatment for attention-deficit/hyperactivity disorder in children, adolescents, and adults in some countries. LDX is a prodrug comprising d-amphetamine covalently link...

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Bibliographic Details
Main Authors: Sharman J, Pennick M
Format: Article
Language:English
Published: Dove Medical Press 2014-11-01
Series:Neuropsychiatric Disease and Treatment
Online Access:http://www.dovepress.com/lisdexamfetamine-prodrug-activation-by-peptidase-mediated-hydrolysis-i-peer-reviewed-article-NDT