Molecular insights for optimizing T cell receptor specificity against cancer

Molecular insights for optimizing T cell receptor specificity against cancer

Cytotoxic CD8 T cells mediate immunity to pathogens and they are able to eliminate malignant cells. Immunity to viruses and bacteria primarily involves CD8 T cells bearing high affinity T cell receptors (TCRs), which are specific to pathogen derived (non-self) antigens. Given the thorough eliminatio...

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Bibliographic Details
Main Authors: Michael eHebeisen, Susanne eOberle, Danilo ePresotto, Daniel E Speiser, Dietmar eZehn, Nathalie eRufer
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Immunology
Subjects:
Immunotherapy
Melanoma
human
Affinity
Cytotoxic T Cells
inhibitory receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00154/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00154/full

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