Connexin hemichannels regulate redox potential via metabolite exchange and protect lens against cellular oxidative damage

Increased oxidative stress contributes to cataract formation during aging. Anterior epithelial cells are a frontline antioxidant defense system with powerful capacities to maintain redox homeostasis and lens transparency. In this study, we report a new molecular mechanism of connexin (Cx) hemichanne...

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Bibliographic Details
Main Authors: Yumeng Quan, Yu Du, Changrui Wu, Sumin Gu, Jean X. Jiang
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002615